The ORACEA® Advantage

Once-daily ORACEA® is a unique formulation of doxycycline that helps break the cycle of inflammation associated with rosacea, reducing papules and pustules without bacterial resistance.1 Working below the antimicrobial threshold, ORACEA® reduces inflammatory lesions of rosacea with a similar efficacy profile to doxycycline 100 mg when administered with metronidazole 1% gel, with the most common side effects reported as GI upsets (nausea, diarrhea), nasopharyngitis and sinusitis.2



Most recently, ORACEA® received high treatment satisfaction ratings by patients and providers in a large-scale community study, where it was reported by patients that they had significant improvements in their quality of life scores observed.3



*No generic equivalent


Proposed Mechanism of Action of Oracea®


Important Safety Information for Oracea®

Oracea® is indicated for the treatment of only inflammatory lesions (papules and pustules) of rosacea in adult patients.

In clinical trials, the most common adverse events reported were nasopharyngitis/pain, gastrointestinal upsets, hypertension and nasal congestion/sinusitis. Oracea® should not be used to treat microbial infections, and should be used only as indicated. This drug is contraindicated in people who have shown hypersensitivity to any of the tetracyclines, and, like other tetracycline drugs, may cause fetal harm when administered to a pregnant woman. Oracea® should not be used during pregnancy, by nursing mothers, or during tooth development (up to the age of 8 years). Although photosensitivity was not observed in clinical trials, Oracea® patients should minimize or avoid exposure to natural or artificial sunlight. All contraindications, warnings, and precautions associated with tetracyclines must be considered before prescribing Oracea®. The efficacy of Oracea® beyond 16 weeks and safety beyond 9 months have not been established.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.